Stratum corneum hydration regulates key epidermal function and serves as an indicator and contributor to other conditions
نویسندگان
چکیده
منابع مشابه
Skin barrier function and stratum corneum hydration
Under normal circumstances, epidermis must be as impermeable as possible except for a small amount of water loss to hydrate the outer layers of the SC. Although all living cells require water to function, some “dead” cells also require water to be metabolically active. As it is the case of corneocytes, epidermis must retain sufficient water to (a) hydrate the outer layers of the SC to maintain ...
متن کاملSASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing
The stratum corneum (SC), the outermost layer of the epidermis, acts as a barrier against the external environment. It is hydrated by endogenous humectants to avoid desiccation. However, the molecular mechanisms of SC hydration remain unclear. We report that skin-specific retroviral-like aspartic protease (SASPase) deficiency in hairless mice resulted in dry skin and a thicker and less hydrated...
متن کاملMechanical Properties of the Human Stratum Corneum: Hydration Effects on Graded Delamination of Human Stratum Corneum
Reinhold Dauskardt Stanford University, Professor Materials Sciences and Engineering The stratum corneum (SC) is the outermost layer of the skin. Its process of reneweal is regulated by various mechanisms, including chemical and structural gradients through the SC thickness. In this study, an in vitro mechanics approach for studying the delamination behavior of SC in the direction perpendicular...
متن کاملOpto-thermal technique for in-vivo stratum corneum hydration measurement
A new method for measuring stratum corneum hydration in-vivo, using opto-thermal transient emission radiometry with 2.94pm Er:YAG excitation and wavelength selective detection, is described. Results on skin recovery following exogenous hydration, skin stripping with Sellotape and wound healing are presented.
متن کاملCharacterization of skin friction coefficient, and relationship to stratum corneum hydration in a normal Chinese population.
BACKGROUND AND OBJECTIVES Studies have demonstrated that some cutaneous biophysical properties vary with age, gender and body sites. However, the characteristics of the skin friction coefficient in different genders and age groups have not yet been well established. In the present study, we assess the skin friction coefficient in a larger Chinese population. METHODS A total of 633 subjects (3...
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ژورنال
عنوان ژورنال: Journal of the European Academy of Dermatology and Venereology
سال: 2019
ISSN: 0926-9959,1468-3083
DOI: 10.1111/jdv.15374